Isoginkgetin inhibits lung cancer cell progression through miR-27a-5p/APEX1 axis

Purpose: To determine the influence of isoginkgetin on progression pulmonary carcinogenesis.
 Methods: A549 cells exposed to were transfected with miR-27a-5p mimetic and suppressor, as well short hairpin RNA against apurinic/apyrimidinic endo-deoxyribonuclease 1 (sh-APEX1) for 24 h. Then, proliferative, migration invasive potential determined using CCK-8, wound healing Transwell assays, respectively. The association between APEX1 was by dual-luciferase reporter assay.
 Results: Isoginkgetin significantly suppressed cell activities (p < 0.05). Moreover, increased expression. Furthermore, suppressor annulled lung cancer progression. More importantly, inhibitor directly targeted APEX1, negatively modulated expression However, knockdown enhancing effect viability, invasion 0.05).
 Conclusion: exerts an anti-lung via miR-27a-5p/APEX1 axis. Thus, it is a therapy management cancer; however, clinical studies are required validate these findings this study.